Treatment of Recurrent Mycosis Fungoides (Including Sézary Syndrome)

For information about the treatments listed below, see the Treatment Option Overview section.

Treatment of recurrent mycosis fungoides including Sézary syndrome may be within a clinical trial and may include the following:

• Radiation therapy with total skin electron beam radiation therapy. In some cases, radiation therapy is given to skin lesions as palliative therapy to reduce tumor size to relieve symptoms and improve quality of life.
• Psoralen and ultraviolet A (PUVA) radiation therapy, which may be given with immunotherapy.
• Ultraviolet B radiation.
• Extracorporeal photopheresis (ECP).
• Systemic chemotherapy with one or more drugs.
• Other drug therapy (topical corticosteroids, retinoid therapy, lenalidomide, histone deacetylase inhibitors).
• Immunotherapy given alone or combined with therapy directed at the skin.
• High-dose chemotherapy, and sometimes radiation therapy, with stem cell transplant.
• Targeted therapy (brentuximab vedotin or mogamulizumab).

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.